Een doorligwond kan zich overal op het lichaam ontwikkelen, afhankelijk van waar de huid blootgesteld wordt aan druk. Het grootste risico lopen echter de plekken waar de druk van het lichaam en de tegendruk van het ondersteunende oppervlak loodrecht uitgeoefend worden op een huidgedeelte op een convex stuk bot met weinig elastisch spierweefsel en onderhuids vetweefsel om de druk te verdelen. De meest voorkomende plaatsen (circa 95% van alle doorligwonden) zijn dan ook het heiligbeen, de hielen, de heupen, de trochanter major en de laterale malleoli.
Voorbeelden van predilectielocaties van doorligwonden:
1) Sacraal gebied
2) Hiel
3) Trochanter
4) Laterale malleolus
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